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In the 124 biopsies that involved non-eloquent areas, complications occurred in 10 cases (8.1 percent). In the 160 biopsies that involved eloquent areas of the brain, complications occurred in nine cases (5.6 percent of the total).

To make that comparison, McPherson’s team studied records of 284 stereotactic needle biopsies performed by 19 Mayfield Clinic neurosurgeons between January 2000 and December 2006. ∻ut until now, researchers had not actually documented that biopsies in eloquent areas were as safe as those in non-eloquent areas.” “Needle biopsies in eloquent areas have generally been acknowledged to be safe, because the needle causes only a small amount of disruption to the brain,” McPherson explains. Complications were defined as the worsening of existing neurological deficits, seizures, brain hemorrhaging and death. Eloquent areas included the brainstem, basal ganglia, corpus callosum, motor cortex, thalamus, and visual cortex. The UC study compared the complication rates of stereotactic biopsies in functional, or “eloquent,” areas of the brain that were associated with language, vision, and mobility to areas that were not associated with critical functions. The retrospective study, led by Christopher McPherson, MD, director of the division of surgical neuro-oncology at UC and a Mayfield Clinic neurosurgeon, was published online in May in the Journal of Neurosurgery. CINCINNATI≺fter a review of 284 cases, specialists at the Brain Tumor Center at the University of Cincinnati (UC) Neuroscience Institute have concluded that performing a stereotactic needle biopsy in an area of the brain associated with language or other important functions carries no greater risk than a similar biopsy in a less critical area of the brain.